Anatomic distribution of periprostatic adipose tissue
نویسندگان
چکیده
منابع مشابه
Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro
BACKGROUND Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown. Thus, this study aimed to determine if periprostatic adipose tissue is linked with aggressive tumor biology in prostate cancer. METHODS Supernatants of whole adipose tissue...
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Altered fatty acid profile of periprostatic adipose tissue in prostate cancer patients: an MR spectroscopic study Palamadai N Venkatasubramanian, George Iordanescu, Kristian Novakovic, Jennifer Doll, Charles Brendler, and Alice M Wyrwicz Radiology, NorthShore University HealthSystem, Evanston, IL, United States, Surgery, NorthShore University HealthSystem, Evanston, IL, United States, Biomedica...
متن کاملTumor cell-educated periprostatic adipose tissue acquires an aggressive cancer-promoting secretory profile.
BACKGROUND/AIMS The microenvironment produces important factors that are crucial to prostate cancer (PCa) progression. However, the extent to which the cancer cells stimulate periprostatic adipose tissue (PPAT) to produce these proteins is largely unknown. Our purpose was to determine whether PCa cell-derived factors influence PPAT metabolic activity. METHODS Primary cultures of human PPAT sa...
متن کاملObesity and prostate cancer: gene expression signature of human periprostatic adipose tissue
BACKGROUND Periprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic organ towards this fat depot. This study aimed to determine the genome-wide expression of genes in PP adipose tissue in obesity/overweight (OB/OW) and prostate cancer patients. METHODS Differentially...
متن کاملMetabolic effects associated with adipose tissue distribution.
Cardiovascular and metabolic risk depends not only on the overall obesity but also fat distribution is more powerfull predictor for risk factors. Adipose tissue produces and secretes a variety of bioactive peptides - adipokines The most recently described adipocyte secretory proteins contribute to the pathogenesis of impaired insulin secretion and insulin resistance, endothelial dysfunction, a ...
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ژورنال
عنوان ژورنال: Cancer
سال: 2003
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.11231